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To set up and run Xenium Ranger, please follow the following steps:
Xenium Ranger 4.0.0 (Sep 2, 2025)
- Self-contained, relocatable tar file. Does not require centralized installation.
- Contains binaries pre-compiled for CentOS 7 and later/RedHat 7.4 or Ubuntu 16.04 and later.
- Runs on Linux systems that meets the minimum compute requirements.
tar.gz compression
Download for Linux 64-bit (tar.gz)File size: 3.5 GBmd5sum: c063db33f59ac7df642ca6b8d3ae6adccurlwgetcurl -o xeniumranger-4.0.0.tar.gz "https://cf.10xgenomics.com/releases/xeniumranger/xeniumranger-4.0.0.tar.gz?Expires=1774623734&Key-Pair-Id=APKAI7S6A5RYOXBWRPDA&Signature=YUGATOaHKJEQamKbJ1w8C1zXWsH753i4hVbyLgVPqgRiqljZTjWex65hWk3CGH~-bmd73RBMFwokC~bOsI7GiORFd8K2ZR4EAtAB4dXvbmxJ1GQgvoMaIbfrRZZIGk6Jz6YWGz7VYv82iJf6-cOEQnSCfBqj4S1aMqlZWm56V5syWEZnDREUgxEn1Uxd8tW7nvLj71HNp2H6WVkYs5HqiBrNHEjILMyhsqHNTHCCIF17ekhamODYK~BPYEwjwuS1CRydFayBbOjrr7ccO0ZL1cfUJI8NeUZ9OmruTkS1HHUSOwCvyW-VMBNFfnKkuXUciu3JR42-Q3cYR2fwWLRqpQ__"tar.xz compression
Download for Linux 64-bit (tar.xz)File size: 2.3 GBmd5sum: 3a1636bd176257c0edad991660b13bfdcurlwgetcurl -o xeniumranger-4.0.0.tar.xz "https://cf.10xgenomics.com/releases/xeniumranger/xeniumranger-4.0.0.tar.xz?Expires=1774623734&Key-Pair-Id=APKAI7S6A5RYOXBWRPDA&Signature=Di4PL9FceMxi72jh3chO8HM-oXVd8TBNoFhD~lCriGrpTBGxZjLIbyLtW3Glp-RQdDMyf~7nnsjfzm6Aadtc93NpcZIC1oD~J9Ez42w~JNrrxZO2PZklB4xcktxW2qE8m0wMj-TwWXXPy7Aiadl7qvNqtWp7AhseSQVhUtdr~~Paeu1Avj1d~vBTCoRaYil28vydlIxlZE8iims5oYKMR19vA1X5R6nmiHP6IH6ByDmHJmjyc057d3u-Lpq7HQ9Mo7bMGfOZRJzG0YOB2Vm33S2U4YPugN9y9l7awt1KbYlDIBTOXicNeRATVJIBpLybClxzufuYS2OnAUKVnuHe0A__"
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Xenium Ranger 4.0.0 highlights
- Supports reanalysis of Xenium Onboard Analysis data up to XOA v4.0.
- Segment previously un-segmentable large cells with the new large cell segmentation feature.
- Substitute a boundary or interior stain with a Xenium Protein image for multimodal cell segmentation.
- Map cell IDs between a Xenium Ranger output and the imported segmentation to join metadata for a third-party analysis.
- And more - see full release notes.
System requirements
System requirements
View the minimum requirements to run Xenium Ranger pipelines
Installation
Xenium Ranger Installation
View instructions on how to install Xenium Ranger