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To set up and run Xenium Ranger, please follow the following steps:
Xenium Ranger 4.0.0 (Sep 2, 2025)
- Self-contained, relocatable tar file. Does not require centralized installation.
- Contains binaries pre-compiled for CentOS 7 and later/RedHat 7.4 or Ubuntu 16.04 and later.
- Runs on Linux systems that meets the minimum compute requirements.
tar.gz compression
Download for Linux 64-bit (tar.gz)File size: 3.5 GBmd5sum: c063db33f59ac7df642ca6b8d3ae6adccurlwgetcurl -o xeniumranger-4.0.0.tar.gz "https://cf.10xgenomics.com/releases/xeniumranger/xeniumranger-4.0.0.tar.gz?Expires=1774624793&Key-Pair-Id=APKAI7S6A5RYOXBWRPDA&Signature=hjoRdrZdFF4XQK6-~KK2AQu5csmf6sUI4IFjgzorCbaa78shtObMyiRZnAOrW~uiiYnED~wC4W96w1CUyc0REsjoFBmoJQb66wwNeWiN4oO7qPy6z40V18Bj3uF1RwnLrEzzGDA8iDDEMF7nYI~lz1AKV2HXqKbzKxcvdi2~PSfj-tDuSzkE9DoMxeCGKdme3Ut~5aUHfCJoiQIicLKgQuiv~veul11bxxzfIMqMMe47~UhBJuokRwHx9iwws2EFomPvVhi6WAUgwdWHwXLOXvQ28cYPkDutmHvKLK4Rbgmxe4Bn4whUoELE8yZbNeh6ZcN566LCTzJKJM1Pxj3wPQ__"tar.xz compression
Download for Linux 64-bit (tar.xz)File size: 2.3 GBmd5sum: 3a1636bd176257c0edad991660b13bfdcurlwgetcurl -o xeniumranger-4.0.0.tar.xz "https://cf.10xgenomics.com/releases/xeniumranger/xeniumranger-4.0.0.tar.xz?Expires=1774624793&Key-Pair-Id=APKAI7S6A5RYOXBWRPDA&Signature=KcCGCz2LXHHn~hjGybbdL0x6bjXpm1KAADTMQ4qxJXlOgulpbX4p-XrpdmeHpswzcyBTCwnMQ222pXnHbBbzMIJ9wdkdoAqSKGr6CGWzWA4GtbXwTxwMVDRQShtvXrHfbcONUsHGtyiYtvYOqYWZT4sYeJDohXxYKBv3fA1QgpkgyV8BU24nyrT161EHH0pm-kZx9vp9wjtcUjzXurpg2PXxPw6jA1mHON2tk6G15qXBL9XrpAg64GJba5vkJpH~UoMbvhpUUMhDwqJzCIFKVx9c2y0Cvqdowl~j4V0d0NKk8FB8SYmfjWrzJZ-QJHs6jUQwqanDM58YIgbY5WnpEg__"
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Xenium Ranger 4.0.0 highlights
- Supports reanalysis of Xenium Onboard Analysis data up to XOA v4.0.
- Segment previously un-segmentable large cells with the new large cell segmentation feature.
- Substitute a boundary or interior stain with a Xenium Protein image for multimodal cell segmentation.
- Map cell IDs between a Xenium Ranger output and the imported segmentation to join metadata for a third-party analysis.
- And more - see full release notes.
System requirements
System requirements
View the minimum requirements to run Xenium Ranger pipelines
Installation
Xenium Ranger Installation
View instructions on how to install Xenium Ranger