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To set up and run Xenium Ranger, please follow the following steps:
Xenium Ranger 4.0.0 (Sep 2, 2025)
- Self-contained, relocatable tar file. Does not require centralized installation.
- Contains binaries pre-compiled for CentOS 7 and later/RedHat 7.4 or Ubuntu 16.04 and later.
- Runs on Linux systems that meets the minimum compute requirements.
tar.gz compression
Download for Linux 64-bit (tar.gz)File size: 3.5 GBmd5sum: c063db33f59ac7df642ca6b8d3ae6adccurlwgetcurl -o xeniumranger-4.0.0.tar.gz "https://cf.10xgenomics.com/releases/xeniumranger/xeniumranger-4.0.0.tar.gz?Expires=1774629793&Key-Pair-Id=APKAI7S6A5RYOXBWRPDA&Signature=R4vMQLi29PYVF~wLZrRzQaidQWJCm8WKevYt1Yo8e574Kpr4dbxSZa2ai03HEGzYPP3097rMfGuOyUchWDLo2ZdzTlvFZu7M6oyh4xhhGFuDKvZL5WpFzSHaq82f9D8a-vI4tSSa3njZ67oS7eKwHAagn7bA7JXYdKpPfJnh9GXvZMFajFA-7UjrHzYev6kwNOtyPRzFYb8r7BLkFsBauUik0jVxb2OjeAA~NYUBEojoNJY0Zu5TWj4Toq5SJckA4dvls8~MMRBDQx5kx~3PzA3gL-cBUmnOTsUxV3k9DKzLIyZ2tad50ydfcdQQiECGHDcYLQPP999NkoEv7bnKSw__"tar.xz compression
Download for Linux 64-bit (tar.xz)File size: 2.3 GBmd5sum: 3a1636bd176257c0edad991660b13bfdcurlwgetcurl -o xeniumranger-4.0.0.tar.xz "https://cf.10xgenomics.com/releases/xeniumranger/xeniumranger-4.0.0.tar.xz?Expires=1774629793&Key-Pair-Id=APKAI7S6A5RYOXBWRPDA&Signature=mdGs1ODfzH~jE9Uf1c2FRt0Hj3LbY2qdyU8JbVNo04~0iutJlbk1NnB8X-pgIjz4ticJzw5c-FLA7GevwW~dot5Lxe1tj~mWXxU7a05Mi6~KStFYgPFiZOb0DtRFM1MIMu0TNvXvF2LI-2uLPNewtfBlE5WZ7BrvhwiGoZqAr982gXLSS3s7oCmQSN~XHAmm3xY6t2cOzwpwTKVxz~Xutg1qlRTtJfGLYUXDEIvh6bYEjrXGNX0-AFd8hW6iubBwMV8zhFeU3-0xsM450S-1eITHtxQ438BorunJEk4fNPYYisds39eMdMsJ~AJIlFCJYwIRVOU5VLeHhwVNtcqgHQ__"
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Xenium Ranger 4.0.0 highlights
- Supports reanalysis of Xenium Onboard Analysis data up to XOA v4.0.
- Segment previously un-segmentable large cells with the new large cell segmentation feature.
- Substitute a boundary or interior stain with a Xenium Protein image for multimodal cell segmentation.
- Map cell IDs between a Xenium Ranger output and the imported segmentation to join metadata for a third-party analysis.
- And more - see full release notes.
System requirements
System requirements
View the minimum requirements to run Xenium Ranger pipelines
Installation
Xenium Ranger Installation
View instructions on how to install Xenium Ranger