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To set up and run Xenium Ranger, please follow the following steps:
Xenium Ranger 4.0.0 (Sep 2, 2025)
- Self-contained, relocatable tar file. Does not require centralized installation.
- Contains binaries pre-compiled for CentOS 7 and later/RedHat 7.4 or Ubuntu 16.04 and later.
- Runs on Linux systems that meets the minimum compute requirements.
tar.gz compression
Download for Linux 64-bit (tar.gz)File size: 3.5 GBmd5sum: c063db33f59ac7df642ca6b8d3ae6adccurlwgetcurl -o xeniumranger-4.0.0.tar.gz "https://cf.10xgenomics.com/releases/xeniumranger/xeniumranger-4.0.0.tar.gz?Expires=1774629602&Key-Pair-Id=APKAI7S6A5RYOXBWRPDA&Signature=hRxxiEgnWph-S1cEr53UsNKJI9wNWLROcKNRRexW53llyQv78crKoeYz0EkAygZf1M1QuEOj6ZoPm6UlW4Yd5igYFlAacRyTa-NVDz1pVzPk4Rc6EmX1FFbgo-pJJ-H5uWJZ-RCCRQXmLJgZyUZKSSR2ILUjjVFlMYSYW~omc3xYhoU1RC3pwlpc0vEHn4TnGSxxfb8vKPIMnJmAxmSSoV1duOUdKt8X5QL3pgPS-IE28DPx67KZeBCogeMlFStrnZrYFO744jpMH~Q-KZR0z63BzJoe~cvKb0A7y9GmQwBYaD-ca5Y~QUUsoICQN4g1gYekZczAYG2DrqPC4yaCTw__"tar.xz compression
Download for Linux 64-bit (tar.xz)File size: 2.3 GBmd5sum: 3a1636bd176257c0edad991660b13bfdcurlwgetcurl -o xeniumranger-4.0.0.tar.xz "https://cf.10xgenomics.com/releases/xeniumranger/xeniumranger-4.0.0.tar.xz?Expires=1774629602&Key-Pair-Id=APKAI7S6A5RYOXBWRPDA&Signature=jfsjyDOHN9H6had3P5cPLm7l5hj--CWTg5KwshhwvXW8uXhWbOKfSZeUDQE5GP0Bqwx6sbD1Qqu9J7JNHVh3ivI~sCCjhxxz7lr8pvNTCP5xKfqFoE6HmmGELZ24AxpiMx1u7sp~vKPbyyknc~-lcOd9~DwTU2fV7KFK7OnmBTnEqPwnadGKq2~Z~lY5Qmqojs3ZXLfLO5K5Db6S7IldcA0Mip-Hwoi1083zYBqv4dm5~2CmXBbHgMx~EwcJO16rE7yahAA1EosP1Wc2OecrsTX8MHordGx7~n-3Wj9e8WbMMKq4AjPiZvUm58arq-Kan17q3mAkJD6FXSW54lqYzQ__"
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Xenium Ranger 4.0.0 highlights
- Supports reanalysis of Xenium Onboard Analysis data up to XOA v4.0.
- Segment previously un-segmentable large cells with the new large cell segmentation feature.
- Substitute a boundary or interior stain with a Xenium Protein image for multimodal cell segmentation.
- Map cell IDs between a Xenium Ranger output and the imported segmentation to join metadata for a third-party analysis.
- And more - see full release notes.
System requirements
System requirements
View the minimum requirements to run Xenium Ranger pipelines
Installation
Xenium Ranger Installation
View instructions on how to install Xenium Ranger