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To set up and run Xenium Ranger, please follow the following steps:
Xenium Ranger 4.0.0 (Sep 2, 2025)
- Self-contained, relocatable tar file. Does not require centralized installation.
- Contains binaries pre-compiled for CentOS 7 and later/RedHat 7.4 or Ubuntu 16.04 and later.
- Runs on Linux systems that meets the minimum compute requirements.
tar.gz compression
Download for Linux 64-bit (tar.gz)File size: 3.5 GBmd5sum: c063db33f59ac7df642ca6b8d3ae6adccurlwgetcurl -o xeniumranger-4.0.0.tar.gz "https://cf.10xgenomics.com/releases/xeniumranger/xeniumranger-4.0.0.tar.gz?Expires=1774635880&Key-Pair-Id=APKAI7S6A5RYOXBWRPDA&Signature=ow0NwaBrxq0rCSa7-vEyep~pu4C7fJ17f~W0zF5VBra9b88VPjT~kgLlf8Lmc0ZorOsG466d5ZVHnLqFUxvGnlhte3b4ANAPi9kWH9LxPRqO-iKoiBW~lAYUr0XbtzhCYcmTVj2ViQrXbyOJOIeEbZIWjyyUthBEi5keoUTHAHeyucbve9KuyVoPYRRCrb05zZ06msg-Et4ELyyQPet6Y45nnqS38CfhqeLzVCpPk-Z1AxbYX~yw2kI-sMYplomqYFNjhiY3XgUR3fViUiooce2v7F6YnvOKGcE5cly2X2RuIEKpaCd-2QwZBsi4zV6kiNq98aqkIEy4f7QykFSu5Q__"tar.xz compression
Download for Linux 64-bit (tar.xz)File size: 2.3 GBmd5sum: 3a1636bd176257c0edad991660b13bfdcurlwgetcurl -o xeniumranger-4.0.0.tar.xz "https://cf.10xgenomics.com/releases/xeniumranger/xeniumranger-4.0.0.tar.xz?Expires=1774635880&Key-Pair-Id=APKAI7S6A5RYOXBWRPDA&Signature=JZUdcUpOA-whs-gQBLK-q~E1ZzEF6x46PPM65UD-wJEUpliAHf0fk2bhc1YnkKYuSjB3UXE63Y7ySCt4xaswOIcQ5JVzHJ5L9szZ4vuIQEy-nnLFPx~yzZsV3UhEyANMK2jAgO-nkMuYKUuX8XuzDB7Re09xxvDb~I1d78efrbcH3TSVcuSPhxPmKwXvkvKkMB9cmN0A6bjtUgV-ZvBfRMRjCMTiXbpjJEcY8yxW98BUHrO4Xnb~Fqq8KMCqXAJH8rCR9GZvc8hDoBzDgHpTmW0uD9Nyi1dUZypXKeI9KRYCJtRNiBQBhTU~C-Ocn~71qV877FIx67Vu8gEWlcZI3w__"
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Xenium Ranger 4.0.0 highlights
- Supports reanalysis of Xenium Onboard Analysis data up to XOA v4.0.
- Segment previously un-segmentable large cells with the new large cell segmentation feature.
- Substitute a boundary or interior stain with a Xenium Protein image for multimodal cell segmentation.
- Map cell IDs between a Xenium Ranger output and the imported segmentation to join metadata for a third-party analysis.
- And more - see full release notes.
System requirements
System requirements
View the minimum requirements to run Xenium Ranger pipelines
Installation
Xenium Ranger Installation
View instructions on how to install Xenium Ranger