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To set up and run Xenium Ranger, please follow the following steps:
Xenium Ranger 4.0.0 (Sep 2, 2025)
- Self-contained, relocatable tar file. Does not require centralized installation.
- Contains binaries pre-compiled for CentOS 7 and later/RedHat 7.4 or Ubuntu 16.04 and later.
- Runs on Linux systems that meets the minimum compute requirements.
tar.gz compression
Download for Linux 64-bit (tar.gz)File size: 3.5 GBmd5sum: c063db33f59ac7df642ca6b8d3ae6adccurlwgetcurl -o xeniumranger-4.0.0.tar.gz "https://cf.10xgenomics.com/releases/xeniumranger/xeniumranger-4.0.0.tar.gz?Expires=1774624589&Key-Pair-Id=APKAI7S6A5RYOXBWRPDA&Signature=jf8dqkQ-idTeaB92DJOJ7E5gYXBmpAsFC2lQDdKs99VdyL~r-Q6GtK6uSoGo1nploJFyAjxIHpl9NXCNmqrygs7x1j2pEpeB9wu9ROZY8B3I0QHgzt5CtcFHaUxSD6Jp~4z0UKVxCAiQFtB8LKRzuBsn8QE2hoVVXDBXt7HKzrEodkaPWmMhnSxm3IF8YnRG6Taxamd5YpJUdMQRyejplvAKcFAKzhxn3QF49j7OBK5IQKfQoXZHwUvOjkjWpYGENaxCALo-uLTCv6b9vmcV29PNgbEmnrIDhJ-ELdlMwp8DgL~ZI4bMhfWfouPy9VbVC2VyKIDMIS4~WTX2s4Gybw__"tar.xz compression
Download for Linux 64-bit (tar.xz)File size: 2.3 GBmd5sum: 3a1636bd176257c0edad991660b13bfdcurlwgetcurl -o xeniumranger-4.0.0.tar.xz "https://cf.10xgenomics.com/releases/xeniumranger/xeniumranger-4.0.0.tar.xz?Expires=1774624589&Key-Pair-Id=APKAI7S6A5RYOXBWRPDA&Signature=Nx6IyvZArtvrJj1euO1hI5n4zPIc0bmkgrqaZXIjefX7ZsgpTRd3vBkwptkI-l3uNDUbTTIeVKMq2GTjf7dXGSydvOJ3mWIOoKV2eu36YJgKs1-JObL9MuTlUO7iILjbhuNYpOXWodxFX-e7KkN32BmJjvMA2vEYTDsy39vj3edzflizLmqVs6ev8HblOd47metrAKb72l5VlJcz2eoLWQyBKtVn202NIn3yQRNFn1LOx3SgL~1IHbOODVnczvi70QbJmZUQxCjYBHK5MyfHa29W76Y8-4m68Yr3erMuWFxcQq8m3rMaMZG5ika3K2u65M2l9~lsaj-rjkZAKxhtVQ__"
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Xenium Ranger 4.0.0 highlights
- Supports reanalysis of Xenium Onboard Analysis data up to XOA v4.0.
- Segment previously un-segmentable large cells with the new large cell segmentation feature.
- Substitute a boundary or interior stain with a Xenium Protein image for multimodal cell segmentation.
- Map cell IDs between a Xenium Ranger output and the imported segmentation to join metadata for a third-party analysis.
- And more - see full release notes.
System requirements
System requirements
View the minimum requirements to run Xenium Ranger pipelines
Installation
Xenium Ranger Installation
View instructions on how to install Xenium Ranger