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To set up and run Xenium Ranger, please follow the following steps:
Xenium Ranger 4.0.0 (Sep 2, 2025)
- Self-contained, relocatable tar file. Does not require centralized installation.
- Contains binaries pre-compiled for CentOS 7 and later/RedHat 7.4 or Ubuntu 16.04 and later.
- Runs on Linux systems that meets the minimum compute requirements.
tar.gz compression
Download for Linux 64-bit (tar.gz)File size: 3.5 GBmd5sum: c063db33f59ac7df642ca6b8d3ae6adccurlwgetcurl -o xeniumranger-4.0.0.tar.gz "https://cf.10xgenomics.com/releases/xeniumranger/xeniumranger-4.0.0.tar.gz?Expires=1774629770&Key-Pair-Id=APKAI7S6A5RYOXBWRPDA&Signature=d1pqUjlgRHEi6XeC3plP-dcnfrcibx-M6KfZw2MfOhXTkbTpus5jK1qvCPb2hroUn5MLfws-6Zjmjk5IQG4Wx6wSHajmVDbyodqn0IPoHtpsm-eme7ESuZseVVxI9tkZzZns7wlW4O1rPrdAkexWFkD-a37YcOcqHY6cM4Pp~wxC03MS6GYx6AKATDslsh1FQRU8ANZzelXdNNVME7A~NjgdXaw-SJncF9HJ82mUEKAuJMHM7bYN3MVRT25y2rIT7rADw5pTjt5glUL1Qlwt00w1VYYIpshY~KEz1rZLJqfhkEXPHNK1o4buIQC19uDcmATNParpbgt4AzmQjrKOrA__"tar.xz compression
Download for Linux 64-bit (tar.xz)File size: 2.3 GBmd5sum: 3a1636bd176257c0edad991660b13bfdcurlwgetcurl -o xeniumranger-4.0.0.tar.xz "https://cf.10xgenomics.com/releases/xeniumranger/xeniumranger-4.0.0.tar.xz?Expires=1774629770&Key-Pair-Id=APKAI7S6A5RYOXBWRPDA&Signature=OnGwFAgE9snCho2b4JjBl6pTngAlft1b6xbetnn98Rv59~jJOrZBMbvWKcj~LkJS7o2Aa7ZYgXBiHrnts9-KR-3OdIeypgGkGOKml8zo001uXUL~7t0X1hQj1n0jwHsJILq9d~egz~J7LWuEj2g1lKHzlJ~Os4~N1~fGAKXPvdEqxFhW5CkyINM7uCRpysojP4eapPy54qc~l27r036kizmqZ0hGiPXpZYHlSPrcYA4bDE5GZuCxnID6natw2Z~BNj0DoWI7hGlBFTESAyBFfwhQJNDcoDcs58mzfHc8m1nXG2Ng7KojAU8TUEUkuH48jXEgeR59v8b7u9Q-vmbY4Q__"
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Xenium Ranger 4.0.0 highlights
- Supports reanalysis of Xenium Onboard Analysis data up to XOA v4.0.
- Segment previously un-segmentable large cells with the new large cell segmentation feature.
- Substitute a boundary or interior stain with a Xenium Protein image for multimodal cell segmentation.
- Map cell IDs between a Xenium Ranger output and the imported segmentation to join metadata for a third-party analysis.
- And more - see full release notes.
System requirements
System requirements
View the minimum requirements to run Xenium Ranger pipelines
Installation
Xenium Ranger Installation
View instructions on how to install Xenium Ranger